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Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
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Reply to B. O'Sullivan et Al

David G Pfister1, Shrujal S Baxi2, Lara A Dunn2

  • 1Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY pfisterd@mskcc.org.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|April 1, 2015
PubMed
Summary

No abstract available in PubMed .

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