Related Experiment Video
Updated: Apr 15, 2026
06:09
Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
Published on: February 9, 2020
13.8K
Lymph Node Yield in Primary Retroperitoneal Lymph Node Dissection for Nonseminoma Germ Cell Tumors
Madhur Nayan1, Michael A S Jewett1, Joan Sweet2
1Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
The Journal of Urology
|April 1, 2015
Summary
More lymph nodes removed during retroperitoneal lymph node dissection for testicular nonseminoma may reduce relapse risk. No clinical factors predicted node yield, but higher node counts correlated with better outcomes.
Area of Science:
- Urology
- Surgical Oncology
- Oncology
Background:
- Lymph node count is crucial for cancer staging and prognosis.
- Limited data exists on the significance of lymph node yield in retroperitoneal lymph node dissection (RPLND) for testicular nonseminoma.
Purpose of the Study:
- To investigate the factors associated with lymph node yield during RPLND for testicular nonseminoma.
- To determine the relationship between lymph node count and relapse risk in these patients.
Main Methods:
- Retrospective analysis of 157 patients undergoing primary open RPLND for clinical stage I/II testicular nonseminoma (1979-2012).
- Node count data available for 111 patients; assessed factors influencing total node count and viable cancer presence.
- Multivariate Cox models evaluated the association between node count and time to relapse, controlling for chemotherapy.
Main Results:
- Median total lymph node count was 28; no clinical or pathological factors correlated with node yield.
- Viable cancer found in 63% of patients; node yield did not predict nodal metastasis.
- Increased total lymph node count was significantly associated with a decreased risk of relapse (HR 0.94, P=0.017).
Conclusions:
- Node yield in primary RPLND for testicular nonseminoma is not influenced by analyzed clinical or pathological variables.
- A higher total lymph node yield may be linked to a reduced risk of disease relapse.
More Related Videos
Related Concept Videos
01:15Secondary Lymphoid Organs
10.5K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.5K
01:23Detailed Structure and Function of Lymph Nodes
6.6K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
6.6K
01:15Development of the Lymphatic System
2.8K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.8K