Radionuclide evaluation of dual chamber pacing: comparison between variable AV intervals and ventricular pacing

We prospectively evaluated changes in left ventricular ejection fraction, end diastolic volume, and stroke volume via radionuclide multigated acquisition study. Comparison was made between ventricular pacing and dual chamber pacing with varying AV intervals. The volumes and changes in ejection fraction were determined at rest, at set increased pacing rates, and during physiological stress. AV sequential pacing shows overall improvement in cardiac function in the majority of patients regardless of left ventricular function. The shorter AV interval would be appropriate for the majority of patients who have an atrial tracking mechanism (adequate intrinsic sensed atrial activity followed by ventricular pacing) and who undergo significant physiological stress.