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Published on: September 11, 2020
Interferometric Detection of Single Gold Nanoparticles Calibrated against TEM Size Distributions
Lixue Zhang1, Sune M Christensen1, Poul Martin Bendix1
1Bio-Nanotechnology Laboratory, Department of Chemistry Nano-Science Center, Lundbeck Foundation Center Biomembranes in Nanomedicine, University of Copenhagen, 2100, Copenhagen, Denmark.
Abstract:
Single nanoparticle analysis: An interferometric optical approach calibrates sizes of gold nanoparticles (AuNPs) from the interference intensities by calibrating their interferometric signals against the corresponding transmission electron microscopy measurements. This method is used to investigate whether size affects the diffusion behavior of AuNPs conjugated to supported lipid bilayer membranes and to multiplex the simultaneous detection of three different AuNP labels.
