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Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
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Strip patch testing does not affect reaction profiles of standard allergens.

Heinrich Dickel1, Burkhard Kreft2, Johannes Geier3

  • 1Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, D-44791, Bochum, Germany.

Contact Dermatitis
|April 1, 2015
PubMed
Summary
This summary is machine-generated.

Tape stripping skin before patch testing did not significantly alter reaction profiles for common allergens. The strip patch test is a reliable method for diagnosing contact allergies, even with standard allergens.

Keywords:
contact allergenspatch testpositivity ratioreaction indexstrip patch test

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Area of Science:

  • Dermatology
  • Allergology
  • Contact Dermatitis Research

Background:

  • Hypotheses suggest positive strip patch test reactions may be irritant, not allergic.
  • Investigating the reliability of strip patch testing for allergic contact dermatitis diagnosis.

Purpose of the Study:

  • To evaluate reaction profiles of baseline series patch test substances applied to tape-stripped skin.
  • To compare reaction index (RI) and positivity ratio (PR) between tape-stripped and conventional patch testing.

Main Methods:

  • 1,228 patients underwent routine strip patch testing with the baseline series (intervention group).
  • Results were compared to 1,161 patients from a historical control group with conventional patch testing.
  • Analysis focused on reactions at D3/D4, RI, and PR for 25 standard allergens.

Main Results:

  • Nickel sulfate, fragrance mix I, cobalt chloride, balsam of Peru, and colophonium showed high positive reaction frequencies in both groups.
  • No significant differences in reaction frequencies were observed between the intervention and control groups.
  • 18 of 25 baseline series substances had good reaction profiles in the intervention group, versus 16 in the control group.

Conclusions:

  • Tape stripping the skin prior to patch testing did not significantly alter the reaction profiles of baseline series substances.
  • The strip patch test demonstrates reliable performance, comparable to conventional methods.
  • The strip patch test is recommended for diagnosing contact allergies, regardless of the standard allergen used, especially when conventional tests may yield false-negative results.