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A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
Published on: January 27, 2026
Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with
Ji-Hyun Lee1, Sungyong You2, Do Young Hyeon2
1Medicinal Bioconvergence Research Center and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea, School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang 790-784, Republic of Korea, Department of New Biology and Center for Plant Aging Research, Institute for Basic Science, DGIST, Daegu 711-873, Republic of Korea and Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea Medicinal Bioconvergence Research Center and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea, School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang 790-784, Republic of Korea, Department of New Biology and Center for Plant Aging Research, Institute for Basic Science, DGIST, Daegu 711-873, Republic of Korea and Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea.
Abstract:
Mammalian cells have cytoplasmic and mitochondrial aminoacyl-tRNA synthetases (ARSs) that catalyze aminoacylation of tRNAs during protein synthesis. Despite their housekeeping functions in protein synthesis, recently, ARSs and ARS-interacting multifunctional proteins (AIMPs) have been shown to play important roles in disease pathogenesis through their interactions with disease-related molecules. However, there are lacks of data resources and analytical tools that can be used to examine disease associations of ARS/AIMPs. Here, we developed an Integrated Database for ARSs (IDA), a resource database including cancer genomic/proteomic and interaction data of ARS/AIMPs. IDA includes mRNA expression, somatic mutation, copy number variation and phosphorylation data of ARS/AIMPs and their interacting proteins in various cancers. IDA further includes an array of analytical tools for exploration of disease association of ARS/AIMPs, identification of disease-associated ARS/AIMP interactors and reconstruction of ARS-dependent disease-perturbed network models. Therefore, IDA provides both comprehensive data resources and analytical tools for understanding potential roles of ARS/AIMPs in cancers.
Insights
This study introduces the Integrated Database for ARSs (IDA), a new resource for exploring the roles of aminoacyl-tRNA synthetases (ARSs) and ARS-interacting multifunctional proteins (AIMPs) in cancer. IDA offers data and tools to investigate their disease associations.
Area of Science:
- Molecular Biology
- Genomics
- Proteomics
Background:
- Mammalian cells utilize aminoacyl-tRNA synthetases (ARSs) for protein synthesis.
- ARSs and ARS-interacting multifunctional proteins (AIMPs) are increasingly implicated in disease pathogenesis.
- Existing resources lack comprehensive data and tools for studying ARS/AIMP disease associations.
Purpose of the Study:
- To develop a integrated database (IDA) for ARSs and AIMPs.
- To provide data and analytical tools for exploring ARS/AIMP roles in cancer.
- To facilitate the understanding of ARS-dependent disease mechanisms.
Main Methods:
- Compilation of cancer genomic and proteomic data for ARS/AIMPs.
- Integration of protein-protein interaction data for ARS/AIMPs.
- Development of analytical tools for disease association exploration and network modeling.
Main Results:
- IDA integrates diverse data including mRNA expression, somatic mutations, copy number variations, and phosphorylation.
- The database includes data on ARS/AIMPs and their interacting proteins across various cancers.
- IDA provides tools for identifying disease-associated interactors and reconstructing disease networks.
Conclusions:
- IDA serves as a valuable resource for cancer research.
- The database and tools enable comprehensive analysis of ARS/AIMP functions in cancer.
- IDA supports the investigation of potential roles of ARS/AIMPs in cancer pathogenesis.
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