[Histologic and ultrastructural changes in the liver in ageing rats and the effects due to food restriction and...

Histologic and ultrastructural changes of the liver in old and non-old Wistar rats and the effects due to persistent restriction of food and exposure to noise were studied. There was increase of hepatocytes with enlarged or double nuclei, and apoptosis as well as fatty change of the liver in the old rats. The incidence of apoptosis and fatty change was lower in those rats with persistent food restriction, but no significant change of the liver was seen in those animals persistently exposed to noisy, environment.