[Differentiation between primary and metastatic ovarian cancers by monoclonal antibodies specific for gastrointestinal tract carcinomas]

Monoclonal antibodies MG7 and MC3, which are highly specific for gastrocolonic carcinomas, were used in immunohistochemical studies of detecting the relevant antigens present in the primary and metastatic carcinomas in ovaries. All 33 cases of primary ovarian carcinomas examined were negative, and positive reaction was obtained in 94.4% of 18 cases of metastatic carcinomas in ovaries. Results of this investigation confirmed the specificity of MG7 and MC3 in differential diagnosis of primary ovarian cancers from metastatic cancers in ovaries originating from the gastrointestinal tract.