Megaloblastic anemia presenting with massive reversible splenomegaly

Area of Science:

• Hematology
• Internal Medicine

Background:

• Megaloblastic anemia (MA) is a common hematologic disorder.
• Splenomegaly is a frequent manifestation, typically mild to moderate.
• Massive splenomegaly is rarely associated with MA.

Observation:

• A patient presented with symptomatic anemia and massive splenomegaly.
• Extensive evaluation excluded other common causes of massive splenomegaly.
• The patient was diagnosed with megaloblastic anemia.

Findings:

• Megaloblastic anemia was confirmed as the cause of massive splenomegaly.
• Therapeutic trial for MA resulted in significant regression of spleen size.
• This case highlights an unusual presentation of MA.

Implications:

• Massive splenomegaly should be considered in the differential diagnosis of megaloblastic anemia.
• Early diagnosis and treatment of MA can effectively manage associated massive splenomegaly.
• Further research may elucidate the mechanisms linking MA and massive splenomegaly.