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Updated: Apr 15, 2026

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel
Published on: June 29, 2015
The effect of ferric chloride on superficial bleeding
Saeed Nouri1, Mohammad Reza Sharif2, Sare Sahba2
1Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Background:
Controlling superficial bleeding, despite all the progress in surgical science, is still a challenge in some settings.
Objectives:
This study assesses the hemostatic effects of ferric chloride and compares it with the standard method (suturing technique) to control superficial bleeding.
Materials And Methods:
In this animal model study, 60 male Wistar rats were used. An incision, 2 cm long and 0.5 cm deep was made on rat skin and the hemostasis time was recorded using ferric chloride at different concentrations (5%, 10%, 15%, 25%, and 50%) and then using a control (i.e. control of bleeding by suturing). The skin tissue was examined for pathological changes. Finally, the obtained data were entered into SPSS (ver. 16) and analyzed using Kruskal-Wallis test, Mann-Whitney, Kolmogorov-Smirnov, and Wilcoxon signed ranks test.
Results:
The hemostasis time for the ferric chloride concentration group was significantly less than for the control group (P < 0.001).
Conclusions:
Ferric chloride may be an effective hemostatic agent to control superficial bleeding in rats.
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