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Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
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The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
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The microbiota: an exercise immunology perspective.

Stéphane Bermon1,2, Bernardo Petriz3,4, Alma Kajėnienė5,6

  • 1LAMHESS, Nice Sophia Antipolis University, France.

Exercise Immunology Review
|April 1, 2015
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Summary
This summary is machine-generated.

Exercise influences the gut microbiota, impacting immune responses. This review explores how physical activity and gut bacteria interact to modulate immunity, highlighting the gut

Keywords:
exercisegutimmunitymicrobiota.

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Area of Science:

  • Microbiology
  • Exercise Physiology
  • Immunology

Background:

  • The gut microbiota comprises microorganisms producing hormonal signaling molecules affecting distant sites.
  • Microbiota is modulated by environmental factors like exercise and disease, with diversity linked to health.
  • Altered gut microbiota is associated with impaired health, while increased diversity enhances metabolic and immune functions.

Purpose of the Study:

  • To review the interaction between gut microbiota, exercise, and immunomodulation.
  • To highlight the gut microbiota's role as an endocrine organ sensitive to exercise-induced physiological changes.

Main Methods:

  • Review of existing experimental and animal studies.
  • Analysis of preliminary data on exercise, probiotics, and immune responses.

Main Results:

  • Preliminary data suggest exercise modulates gut microbiota.
  • Gut microbiota plays a role in immune modulation and is sensitive to exercise.

Conclusions:

  • The gut microbiota acts as an endocrine organ.
  • Exercise and gut microbiota have a significant interplay influencing the immune system.