[Age-related features of peripheral blood cell adaptive reaction in women with chronic obstructive pyelonephritis]

The aim of the study was to evaluate the adaptive changes of peripheral blood cells of recurrence inflammation in aged women with chronic obstructive pyelonephritis (COPN). An analysis of clinical and laboratory data was carried out on 50 women who were distributed into two age periods: under 55 years (the comparison group) and over 65 years. In women of 65+, during recurrence of COPN, the degree of leukocyte increase, neutrophils, monocytes and erythrocyte sedimentation rate (ESR) reached 90,1, 20,8, 71,4 and 31,6%, whereas lymphocyte count was less by 2,8 times in comparison with remission. In women under 55 years (in recurrence of COPN), degree of leukocyte increase was 87% (p<0,001), neutrophils--4, 8% (p<0,05), monocytes--in 2,04 times (p<0,001), ESR was less in 3,1 times (p<0,001) and lymphocyte count was less than 19,5% (p>0,05). The manifestation of neutrophilocytosis and lymphocytopenia might be due to age-related features of adaptive reaction in peripheral blood cells during the COPN recurrence.