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Updated: Apr 15, 2026
Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
Cup-to-Disc Ratio From Heidelberg Retina Tomograph 3 and High-Definition Optical Coherence Tomography Agrees Poorly
Shamira A Perera1, Li Lian Foo, Carol Y L Cheung
1*Singapore Eye Research Institute & Singapore National Eye Center †Duke-NUS Graduate Medical School ‡Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Purpose:
To investigate the agreement of vertical cup-to-disc ratio (VCDR) measured from Heidelberg Retina Tomograph 3 (HRT-3), high-definition optical coherence tomography (HD-OCT), and clinical grading.
Methods:
A total of 933 consecutive subjects underwent optic nerve head imaging with HRT-3 and HD-OCT during a single visit. The vertical dimensions of the disc and cup were measured by slit-lamp examination using an eyepiece graticule. Bland-Altman plots evaluated the agreement in the VCDR obtained by the 2 instruments and clinical grading.
Results:
We found a significant trend for the difference in VCDR measured clinically and with HRT and HD-OCT (P<0.001 for both). The mean VCDR differed significantly between clinical measurement and that evaluated by HRT and HD-OCT, respectively (0.40 ± 0.12 vs. 0.37 ± 0.21 and 0.40 ± 0.12 vs. 0.50 ± 0.14, P<0.001 for both), with significantly poor correlation (r(2)=0.35 and 0.34, P<0.001 for both).
Conclusions:
In general, there is poor correlation and a lack of agreement of VCDR measured using HRT-3, HD-OCT, and clinical grading. HD-OCT has somewhat better agreement with clinical measurements of VCDR. Compared with clinical grading, HD-OCT tended to overestimate VCDR, whereas HRT-3 tended to underestimate it.
