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Nanodiscs as a Modular Platform for Multimodal MR-Optical Imaging.

Christiane E Carney1, Ivan L Lenov2, Catherine J Baker2

  • 1†Department of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.

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Tetramethylrhodamine (TMR) tagged nanodiscs efficiently solubilize lipophilic MR contrast agents for multimodal cellular imaging. Monomeric agent-loaded nanodiscs show superior cell labeling and image contrast at 7 T compared to multimeric agents.

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Medical Imaging

Background:

  • Nanodiscs are self-assembled discoidal particles comprising a lipid bilayer and membrane scaffold proteins (MSP).
  • They are utilized for solubilizing membrane proteins and delivering therapeutic phospholipids.
  • Existing methods for cellular imaging using contrast agents have limitations in efficiency and specificity.

Purpose of the Study:

  • To develop tetramethylrhodamine (TMR) tagged nanodiscs for multimodal cellular imaging.
  • To investigate the incorporation and performance of lipophilic MR contrast agents within nanodiscs.
  • To compare the efficacy of nanodiscs loaded with monomeric versus multimeric contrast agents for cell labeling and imaging.

Main Methods:

  • Self-assembly of nanodiscs with incorporated tetramethylrhodamine (TMR) tags.
  • Incorporation of both monomeric and multimeric Gadolinium(III)-based MR contrast agents into nanodiscs.
  • Cellular labeling experiments and Magnetic Resonance (MR) imaging at 7 Tesla (7 T).

Main Results:

  • Tetramethylrhodamine (TMR) tagged nanodiscs successfully solubilized lipophilic MR contrast agents.
  • Nanodiscs containing monomeric Gd(III)-based contrast agents (ND2) exhibited high cell labeling efficiency.
  • ND2 demonstrated significantly enhanced image contrast at 7 T compared to nanodiscs with multimeric agents (ND1) and Prohance.

Conclusions:

  • Tetramethylrhodamine (TMR) tagged nanodiscs are effective carriers for lipophilic MR contrast agents.
  • Monomeric contrast agent-loaded nanodiscs offer superior performance for cellular imaging applications.
  • These multimodal nanoparticles hold promise for advanced cellular imaging and diagnostics.