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Updated: Apr 15, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Bullous pemphigoid and neurological disease: statistics from a dermatology service
Monica Jidid Mateus Tarazona1, Amanda Nascimento Cavalleiro de Macedo Mota1, Alexandre Carlos Gripp1
1Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Abstract:
Bullous pemphigoid (BP) is an autoimmune, acquired, cutaneous disease caused by the production of autoantibodies against hemidesmosomes' components in the basement membrane. The estimated incidence in Europe ranges from 7 to 43 cases per million inhabitants per year. Several studies have reported an association between BP and neurological disorders (ND). Our cohort of Bullous pemphigoid and ND is the first in Brazil and showed a significantly high prevalence of neurological and/or psychiatric diseases, especially cerebrovascular accident (CVA) and dementia, in agreement with the prevalence reported in several studies published in the medical literature in recent years.
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