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Interregional Coevolution Analysis Revealing Functional and Structural Interrelatedness between Different Genomic
Gabriel Gonzalez1, Kanako O Koyanagi1, Koki Aoki2
1Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Japan.
Journal of Virology
|April 3, 2015
Summary
Human mastadenovirus D (HAdV-D) evolves through frequent recombination, yet essential protein interactions are preserved. Coevolution analysis reveals recombination hotspots and conserved regions, driven by natural selection to maintain vital functions.
Area of Science:
- Virology
- Molecular Evolution
- Genomics
Background:
- Human mastadenovirus D (HAdV-D) exhibits extensive type diversity, attributed to frequent intertypic recombination.
- Paradoxically, protein component replacement in multiprotein systems can cause malfunction, suggesting constraints on recombination.
Purpose of the Study:
- To resolve the paradox of extensive recombination versus functional constraints in HAdV-D evolution.
- To identify genomic regions that have coevolved and understand the role of recombination.
Main Methods:
- Interregional coevolution analysis of 45 HAdV-D types.
- Development of a novel method to detect conserved genomic regions and recombination patterns.
Main Results:
- Approximately 70% of the HAdV-D genome shows coevolutionary patterns.
- Intertypic recombination is concentrated in limited hotspot regions, avoiding functionally interacting protein-coding regions.
- Coevolving regions encode physically interacting proteins essential for viral function.
Conclusions:
- Natural selection preserves functionally integrated genomic regions in HAdV-D, despite frequent intertypic recombination.
- The study predicts previously unknown protein-protein interactions within HAdV-D.
- This approach identifies purifying selection against disruptive recombination events.
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