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Experimental study of taurine antitoxic activity in the model of chronic epinephrine intoxication

O N Oleynikova1, L M Makarova, V E Pogoreliy

  • 1Pharmacology with Course of Clinical Pharmacology Department, Pyatigorsk Medical-Pharmaceutical Institute, Branch of the Volgograd State Medical University, Volgograd, Russia.

Advances in Experimental Medicine and Biology
|April 3, 2015
PubMed
Abstract

No abstract available in PubMed .

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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