Related Experiment Video
Updated: Apr 15, 2026
Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach
Published on: January 24, 2018
Outcome Domains and Measures in Total Joint Replacement Clinical Trials: Can We Harmonize Them? An OMERACT
Jasvinder A Singh1, Michael Dohm1, Andrew P Sprowson1
1From the Birmingham Veterans Affairs Medical Center and University of Alabama at Birmingham, Birmingham, Alabama; University of Arizona, Tucson, Arizona, USA; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK; Institute of Rheumatology and Orthopedics, Royal Prince Alfred Hospital; Sydney Medical School, University of Sydney, Sydney, Australia; Sorbonne Universités, UPMC Univ Paris 06, Institut Pierre Louis d'Epidémiologie et de Santé Publique; AP-HP, Pitié Salpêtrière Hospital, Department of Rheumatology, Paris, France; Department of Medicine and Women's College Hospital, University of Toronto, Toronto, Ontario, Canada; Virginia Commonwealth University, Richmond, Virginia, USA; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne; Monash Department of Clinical Epidemiology, Cabrini Hospital, Melbourne, Victoria, Australia.J.A. Singh, MD, MPH, Professor of Medicine and Epidemiology, Birmingham VA Medical Center and University of Alabama at Birmingham; M. Dohm, MD, Assistant Professor of Medicine and Orthopedics, University of Arizona; A.P. Sprowson, MD, FRCS, Associate Professor of Trauma and Orthopaedics, Warwick Clinical trials Unit, University of Warwick; P.D. Wall, MBChB (Hons), MRCS (Edin), PhD, Orthopaedic Speciality Registrar, Warwick Clinical Trials Unit, University of Warwick; B.L. Richards, MBBS (Hons), MMed (Clin Epi), MSports Med, Senior Clinical Lecturer, Institute of Rheumatology and Orthopaedics, Royal Prince Alfred Hospital and Sydney Medical School, University of Sydney; L. Gossec, MD, PhD, Professor of Rheumatology, Sorbonne Universités, UPMC Univ Paris 06, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Department of Rheumatology; G.A. Hawker, MD, MSc, Professor of Medicine, Department of Medicine and Women's College Hospital, University of Toronto; D.L. Riddle, PhD, Professor of Medicine, Virginia Commonwealth University; R. Bu
Objective:
To develop a plan for harmonizing outcomes for people undergoing total joint replacement (TJR), to achieve consensus regarding TJR outcome research.
Methods:
The TJR working group met during the 2014 Outcome Measures in Rheumatology (OMERACT) 12 meeting in Budapest, Hungary. Multiple conference calls preceded the face-to-face meeting. Brief presentations were made during a 1.5-h meeting, which included an overview of published systematic reviews of TJR trials and the results of a recent systematic review of TJR clinical trial outcome domains and measures. This was followed by discussion of potential core set areas/domains for TJR clinical trials (as per OMERACT Filter 2.0) as well as the challenges associated with the measurement of these domains.
Results:
Working group participants discussed which TJR clinical trial outcome domains/areas map to the inner versus outer core for core domain set. Several challenges were identified with TJR outcomes including how to best measure function after TJR, elucidating the source of the pre- and post-TJR joint pain being measured, joint-specific versus generic quality of life instruments and the importance of patient satisfaction and revision surgery as outcomes. A preliminary core domain set for TJR clinical trials was proposed and included pain, function, patient satisfaction, revision, adverse events, and death. This core domain set will be further vetted with a broader audience.
Conclusion:
An international effort with active collaboration with the orthopedic community to standardize key outcome domains and measures is under way with the TJR working group. This effort will be further developed with new collaborations.
More Related Videos
09:51The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
Published on: September 7, 2022
06:28Anterior Cruciate Ligament Transection and Synovial Fluid Lavage in a Rodent Model to Study Joint Inflammation and Posttraumatic Osteoarthritis
Published on: September 2, 2025
Related Concept Videos
01:11Clinical Trials: Overview
01:16Clinical Trials
There are four phases in a clinical trial. A phase one...
01:09Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
01:23Knee Joint
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
01:10Ankle Joint