[Parameters of granulocyte proliferation in chronic myeloid leukemia and their prognostic value]

A total of 112 patients with chronic myeloid leukemia were examined over time for the parameters of the proliferation of bone marrow and peripheral blood granulocytes. In the phase of blast crisis, the bone marrow demonstrated a significant rise of the portion of the G2 cells and of the mitotic index. The portion of the cells undergoing DNA synthesis in the chronic phase of the disease was not dependent on its duration. The parameters such as the mitotic index and the portion of the G2 cells in the bone marrow as well as the percentage of the cells in the S-phase in the peripheral blood correlated negatively with the patients' survival.