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Lower serum 25 (OH) D concentrations in type 1 diabetes: A meta-analysis
Rennan Feng1, Yanchuan Li1, Guoqiang Li2
1Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China; National Key Discipline, Harbin Medical University, Harbin, China.
Objective:
Vitamin D may have protective effects against type 1 diabetes (T1D). However, the results of current cross-sectional studies have been inconsistent. We aimed to examine the association of serum vitamin D and T1D by conducting a meta-analysis.
Methods:
Multiple databases were searched until April 2014 to identify relevant studies. The search term was "serum vitamin D" and "type 1 diabetes". Random effects model was used to calculate the pooled risk estimate. The data were accessed by software Review manager 5.2.
Results:
We included a total of 23 studies (11 studies with 1900 participants of children or adolescents and 13 studies with 3494 participants of adults) in our meta-analysis. In children or adolescents, serum 25(OH) D in T1D was 5.69 ng/ml [95% confidence interval (CI) (2.82-8.55, P<0.0001) lower than in healthy controls. In adults, serum 25(OH) D in T1D was 2.61 ng/ml [95% confidence interval (CI) (1.13-4.09, P=0.0005) lower than in healthy controls. We did not find evidence of publication bias.
Conclusion:
Serum 25OHD is significantly lower in patients with T1D than in healthy controls.
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