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Published on: August 21, 2021
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Creative implementation of 3Rs principles within industry programs: beyond regulations and guidelines.
Natalie A Bratcher1, Gregory R Reinhard2
1AbbVie, North Chicago, Illinois, USA. Natalie.Bratcher@abbvie.com.
Summary
Institutions are advancing the 3Rs (Replacement, Reduction, Refinement) in animal research beyond regulations. Creative strategies enhance animal welfare and scientific integrity.
Area of Science:
- Laboratory animal science
- Biomedical research ethics
Background:
- The 3Rs (Replacement, Reduction, Refinement) are established principles in animal research.
- Evolving institutional cultures and approaches aim to exceed current 3Rs regulations.
Purpose of the Study:
- To review legal mandates and guidelines for the 3Rs in animal research.
- To present creative strategies for implementing the 3Rs to improve animal welfare and scientific outcomes.
Main Methods:
- Review of regulatory documents (Animal Welfare Act, PHS Policy, etc.).
- Exploration of creative institutional paradigms and resources for 3Rs implementation.
- Discussion of dedicated roles, fellowships, committees, consortia, awards, and volunteer opportunities.
Main Results:
- Existing regulations provide a foundation for the 3Rs.
- Creative approaches, including dedicated roles and collaborative initiatives, foster robust animal welfare cultures.
- Enhanced 3Rs implementation benefits both animal welfare and scientific advancement.
Conclusions:
- Adherence to regulations is crucial for foundational animal care and science.
- Proactive and creative 3Rs strategies are essential for advancing animal welfare and research quality.
- Fostering a strong animal welfare culture through innovative 3Rs practices maximizes benefits for animals and science.
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