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Inflammation

Inflammation

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

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Updated: Apr 15, 2026

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Published on: November 26, 2018

Nonclassical patrolling monocyte function in the vasculature.

Graham Thomas¹, Robert Tacke¹, Catherine C Hedrick¹

¹From the Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA.

Arteriosclerosis, Thrombosis, and Vascular Biology

|April 4, 2015

Summary

This summary is machine-generated.

Nonclassical patrolling monocytes patrol the vasculature, distinct from classical monocytes. These unique immune cells clear debris, aid wound healing, and resolve inflammation.

Keywords:

atherosclerosis inflammation macrophages monocytes

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Last Updated: Apr 15, 2026

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

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Published on: November 26, 2018

Imaging Neutrophils and Monocytes in Mesenteric Veins by Intravital Microscopy on Anaesthetized Mice in Real Time

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Published on: November 16, 2015

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Published on: October 17, 2017

Area of Science:

Immunology
Cell Biology
Vascular Biology

Background:

Nonclassical patrolling monocytes possess a unique capacity for endothelial surveillance.
These cells differ phenotypically and functionally from classical monocyte subsets.
Patrolling monocytes play roles in vascular homeostasis and inflammatory responses.

Purpose of the Study:

To review the distinct characteristics and functions of patrolling monocytes.
To highlight their roles in the vasculature and inflammatory disease settings.
To differentiate patrolling monocytes from classical monocyte subsets.

Main Methods:

Comparative analysis of monocyte subsets based on surface markers (e.g., CX3CR1, Ly6C, CD14, CD16, CCR2).
Review of existing literature on monocyte functions in homeostatic and inflammatory conditions.
Examination of monocyte roles in vascular surveillance, debris clearance, and tissue repair.

Main Results:

Patrolling monocytes (CX3CR1highLy6C- in mice, CX3CR1highCD14dimCD16+ in humans) are distinct from classical monocytes (CCR2highLy6C+ in mice, CCR2highCD14+CD16- in humans).
These cells actively patrol the vascular endothelium.
They contribute to clearing vascular debris, wound healing, and inflammation resolution.

Conclusions:

Patrolling monocytes are crucial for maintaining vascular health and resolving inflammation.
Understanding their unique functions offers insights into inflammatory diseases.
Further research into patrolling monocytes may reveal therapeutic targets.