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Nonclassical patrolling monocyte function in the vasculature

Graham Thomas1, Robert Tacke1, Catherine C Hedrick1

  • 1From the Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA.

Arteriosclerosis, Thrombosis, and Vascular Biology
|April 4, 2015
PubMed

Nonclassical patrolling monocytes are characterized by their unique ability to actively patrol the vascular endothelium under homeostatic and inflammatory conditions. Patrolling monocyte subsets (CX3CR1(high)Ly6C(-) in mouse and CX3CR1(high)CD14(dim)CD16(+) in humans) are distinct from the classical monocyte subsets (CCR2(high)Ly6C(+) in mouse and CCR2(high)CD14(+)CD16(-) in humans) and exhibit unique functions in the vasculature and inflammatory disease. Patrolling monocytes function in several disease settings to remove damaged cells and debris from the vasculature and have been associated with wound healing and the resolution of inflammation in damaged tissues. This review highlights the unique functions of these patrolling monocytes in the vasculature and during inflammation.

Keywords:
atherosclerosisinflammationmacrophagesmonocytes

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