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Collapsing glomerulopathy following anabolic steroid use in a 16-year-old boy with IgA nephropathy
S M Matthai1, G Basu2, S Varughese2
1Department of Pathology, Central Electron Microscopy Unit, Wellcome Trust Research Laboratory, Vellore, Tamil Nadu, India.
Insights
This study reports a case of collapsing glomerulopathy (CG) in a teen with IgA nephropathy (IgAN) after anabolic steroid use. It suggests steroids may trigger CG in those with existing kidney conditions.
Area of Science:
- Nephrology
- Podocytology
- Renal Pathology
Background:
- Collapsing glomerulopathy (CG) is a severe podocytopathy seen in various conditions.
- Anabolic steroid use is linked to CG, primarily in bodybuilders without known kidney disease.
Abstract:
Collapsing glomerulopathy (CG) is a proliferative podocytopathy, increasingly recognized in a variety of disease conditions. We report a case of CG in a 16-year-old boy with IgA nephropathy (IgAN) who presented with acute kidney injury, marked proteinuria and hypertension following a short period of anabolic steroid use. Although CG has been associated with long-term anabolic steroid use among body builders, there is no data on the effect of anabolic steroid use in persons with underlying renal disease like IgAN. We postulate that development of CG in our patient could be temporally linked to intake of body-building steroids along with a predisposing background renal disease of IgAN.
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