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MRI and PET in Mouse Models of Myocardial Infarction
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Current image acquisition options in PET/MR.

Ronald Boellaard1, Harald H Quick2

  • 1Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.

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Summary
This summary is machine-generated.

Whole-body PET/MR hybrid imaging offers advanced soft tissue contrast and PET quantification. Challenges in MR-based attenuation correction (AC) for PET/MR imaging are being addressed through innovative research and new acquisition techniques.

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Area of Science:

  • Medical Imaging
  • Radiophysics
  • Biomedical Engineering

Background:

  • Whole-body PET/MR hybrid imaging integrates PET's sensitivity and MR's soft tissue contrast.
  • Clinical evaluation of PET/MR is ongoing, highlighting the need for technological advancements.

Purpose of the Study:

  • To review current image acquisition options in PET/MR hybrid imaging.
  • To discuss challenges and solutions for MR-based attenuation correction (AC) in PET/MR.

Main Methods:

  • Review of current PET/MR imaging technologies and acquisition protocols.
  • Analysis of challenges in MR-based attenuation correction (AC), including tissue segmentation, bone, field of view limitations, and lung imaging.
  • Exploration of time-of-flight (TOF) PET for improved AC accuracy.

Main Results:

  • MR-based AC is essential for PET/MR quantification due to the absence of CT data.
  • Key challenges in MR-based AC include limited tissue segmentation, handling of bone, image truncation, and respiratory motion artifacts affecting lung segmentation.
  • Time-of-flight (TOF) PET acquisition and reconstruction show promise for enhancing AC accuracy.

Conclusions:

  • Accurate MR-based attenuation correction (AC) is critical for quantitative PET/MR imaging.
  • Addressing challenges in MR-based AC requires interdisciplinary research and innovative solutions.
  • Advancements in PET/MR acquisition, including TOF, are crucial for improving image quality and quantification.