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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
Published on: September 12, 2011
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Idiosyncratic connectivity in autism: developmental and anatomical considerations
1Department of Psychology, University of Miami, PO Box 248185-0751, Coral Gables, FL 33124, USA; Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL, USA.
Trends in Neurosciences
|April 6, 2015
Summary
Autism brain connectivity is unique to each individual, challenging previous general theories. A developmental view across brain regions is needed to understand these differences.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Autism Spectrum Disorder Research
Background:
- Previous research often characterized autism spectrum disorder (ASD) brain connectivity as generally under- or over-connected.
- These broad categorizations may not capture the nuanced reality of neural differences in ASD.
Purpose of the Study:
- To investigate individualized patterns of functional brain connectivity in adults with autism spectrum disorder.
- To challenge simplistic, generalized models of brain connectivity in ASD.
Main Methods:
- Analysis of functional connectivity in the brains of adults diagnosed with autism spectrum disorder.
- Examination of both cortical and subcortical brain regions.
Main Results:
- Demonstration of unique, individualized alterations in functional connectivity among adults with ASD.
- Evidence suggesting that generalized models of under- or over-connectivity are insufficient.
Conclusions:
- Functional brain connectivity in autism spectrum disorder is highly personalized.
- A developmental perspective incorporating both cortical and subcortical brain areas is crucial for a comprehensive understanding of ASD atypicalities.
