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Autism Spectrum Disorder

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Related Experiment Video

Updated: Apr 15, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Developmental changes in large-scale network connectivity in autism.

Jason S Nomi¹, Lucina Q Uddin²

¹Department of Psychology, University of Miami, Coral Gables, FL, USA.

Neuroimage. Clinical

|April 7, 2015

Summary

This summary is machine-generated.

Autism spectrum disorder (ASD) shows changing brain connectivity across development. Young children with ASD have hyper-connectivity, adolescents show altered between-network connectivity, and adults have typical connectivity patterns.

Keywords:

Autism spectrum disorder Functional connectivity Independent component analysis Resting state fMRI Salience network

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A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

Area of Science:

Neuroscience
Developmental Psychology
Genetics

Background:

Autism spectrum disorder (ASD) is associated with disrupted cortical connectivity.
Previous research shows mixed results of hypo- and hyper-connectivity in ASD.
A developmental theory suggests hyper-connectivity in young children and hypo-connectivity in older individuals with ASD.

Purpose of the Study:

To test the developmental hypothesis of brain connectivity in autism spectrum disorder (ASD).
To examine age-related differences in functional brain connectivity in ASD compared to typical development (TD).

Main Methods:

Utilized resting-state functional connectivity analysis (ICA and dual regression) in a large sample.
Examined within- and between-network connectivity across three age cohorts: children, adolescents, and adults.
Compared individuals with ASD to age- and IQ-matched typically developing (TD) individuals.

Main Results:

Children (≤11 years) with ASD showed hyper-connectivity within networks and decreased between-network connectivity compared to TD children.
Adolescents (11-18 years) with ASD had typical within-network connectivity but decreased between-network connectivity.
Adults with ASD exhibited no significant differences in within- or between-network connectivity compared to TD adults.

Conclusions:

Functional connectivity differences in ASD are not uniform and vary across the lifespan.
A developmental perspective and age-stratification are crucial for understanding atypical brain connectivity in autism.
These findings refine our understanding of the neurobiology of ASD across different age groups.