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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

360
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
360
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

851
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
851
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

391
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
391
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

505
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
505
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

896
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
896
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.3K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Updated: Apr 15, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

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Update on pediatric psoriasis.

Nanette B Silverberg1

  • 1Department of Dermatology, 1090 Amsterdam Ave, Ste 11D, New York, NY 10025, USA. nsilverb@chpnet.org.

Cutis
|April 7, 2015
PubMed
Summary
This summary is machine-generated.

Pediatric psoriasis is linked to metabolic syndrome, including obesity and high blood pressure. Recent research highlights a generalized inflammatory nature, emphasizing lifestyle changes and weight control for managing this chronic skin condition.

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Area of Science:

  • Dermatology
  • Pediatrics
  • Metabolic Health

Background:

  • Pediatric psoriasis, a chronic inflammatory skin condition, constitutes about one-third of all psoriasis cases.
  • Emerging evidence indicates pediatric psoriasis shares similarities with adult psoriasis, being associated with a generalized inflammatory diathesis.

Purpose of the Study:

  • To review recent studies (last 2 years) on pediatric psoriasis.
  • To highlight the connection between pediatric psoriasis and metabolic syndrome components.

Main Methods:

  • Literature review of studies published within the last two years.
  • Focus on research pertinent to pediatric psoriasis and its systemic associations.

Main Results:

  • Pediatric psoriasis is increasingly recognized as part of a broader inflammatory condition.
  • Associated metabolic syndrome factors include obesity, hypertriglyceridemia, hypertension, and insulin resistance.

Conclusions:

  • A shift in understanding pediatric psoriasis towards a systemic inflammatory disorder is occurring.
  • Management strategies now emphasize lifestyle modifications, weight control, and systemic therapies alongside dermatological treatment.