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Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
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Microcystic Adnexal Carcinoma-like Neoplasm in a Patient With POT1 Mutation

Margaux P Games1, Laurel Schwartz1, Jules B Lipoff1

  • 1Margaux P. Games is from Drexel University College of Medicine, Philadelphia, Pennsylvania. Dr. Schwartz is from Advanced Dermatology and Cosmetic Surgery, Fort Washington, Pennsylvania. Dr. Lipoff is from the Department of Dermatology, Lewis Katz School of Medicine, Temple University, Philadelphia.

Cutis
|July 7, 2026
PubMed
Summary

A POT1 gene mutation was identified in a patient with multiple skin cancers, including microcystic adnexal carcinoma. This finding suggests a potential link between POT1 mutations and susceptibility to various skin cancers beyond melanoma.

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