Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A class of deep intronic <i>IGHMBP2</i> variants activate a shared cryptic splice donor, enabling correction of select variants with a single antisense oligonucleotide.

medRxiv : the preprint server for health sciences·2026
Same author

Monoallelic POLR3A Variants Cause Early-Onset Peripheral Neuropathy.

Annals of neurology·2026
Same author

Research recommendations for the HEAL Initiative: A path forward for pain research.

The journal of pain·2026
Same author

HPV-related Vulvar Disease.

Clinical obstetrics and gynecology·2026
Same author

Recurrent Papillary Apocrine Carcinoma of the Vulva.

The American Journal of dermatopathology·2026
Same author

Visual recognition and medical dermatology learning needs identified through continuing certification program assessments of the American Board of Dermatology.

Journal of the American Academy of Dermatology·2026

Related Experiment Video

Updated: Apr 15, 2026

Author Spotlight: Exploring Peripheral Mechanisms of Neuropathic Pain in Trigeminal Nerve Injury
04:39

Author Spotlight: Exploring Peripheral Mechanisms of Neuropathic Pain in Trigeminal Nerve Injury

Published on: February 9, 2024

3.7K

Trigeminal trophic syndrome with histopathologic correlation.

Lindsey B Dolohanty1, Steven J Richardson, David N Herrmann

  • 1990 South Ave, Ste 206, Rochester, NY 14620, USA. lindsey_dolohanty@urmc.rochester.edu.

Cutis
|April 7, 2015
PubMed
Summary
This summary is machine-generated.

Trigeminal trophic syndrome (TTS) can cause severe itching and pain, even without nerve damage in the skin. Skin biopsy in this case revealed no innervation despite reported symptoms, highlighting a unique presentation.

More Related Videos

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
09:35

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

19.9K
In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Trigeminal Ganglia
07:55

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Trigeminal Ganglia

Published on: August 1, 2025

1.4K

Related Experiment Videos

Last Updated: Apr 15, 2026

Author Spotlight: Exploring Peripheral Mechanisms of Neuropathic Pain in Trigeminal Nerve Injury
04:39

Author Spotlight: Exploring Peripheral Mechanisms of Neuropathic Pain in Trigeminal Nerve Injury

Published on: February 9, 2024

3.7K
Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
09:35

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

19.9K
In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Trigeminal Ganglia
07:55

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Trigeminal Ganglia

Published on: August 1, 2025

1.4K

Area of Science:

  • Neurology
  • Dermatology
  • Pathology

Background:

  • Trigeminal trophic syndrome (TTS) is a rare condition characterized by facial ulcerations.
  • It is often associated with trigeminal nerve damage, commonly from herpes zoster (HZ).
  • Symptoms can include chronic pain and intractable itching.

Observation:

  • A 49-year-old woman presented with symptoms of TTS affecting the V1 branch of the trigeminal nerve.
  • She reported intractable itching and chronic pain.
  • Skin biopsy histology of the affected scalp showed a complete absence of neuronal innervation.

Findings:

  • The case highlights an uncommon presentation of TTS with severe sensory symptoms despite a lack of detectable nerve fibers in the affected skin.
  • Histological findings correlated with the V1 branch of the trigeminal nerve involvement secondary to herpes zoster.
  • This suggests a complex mechanism underlying the symptoms in TTS.

Implications:

  • The findings challenge the traditional understanding of TTS pathophysiology, suggesting that symptoms may arise from mechanisms other than direct peripheral nerve damage.
  • This case underscores the importance of detailed histological examination in diagnosing and understanding TTS.
  • Further research is needed to elucidate the neurobiological basis of itching and pain in the absence of innervation in TTS and postherpetic neuralgia.