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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Use of computer decision support in an antimicrobial stewardship program (ASP)
R S Evans1, J A Olson2, E Stenehjem3
1Medical Informatics, Intermountain Healthcare, University of Utah , Salt Lake City, Utah ; Biomedical Informatics, University of Utah, University of Utah , Salt Lake City, Utah.
New applications improved antimicrobial stewardship programs (ASPs) by providing timely patient data, enabling efficient audits and better antimicrobial use. This enhances clinical decision-making and patient care.
Area of Science:
- Healthcare Informatics
- Clinical Pharmacy
- Infectious Diseases
Background:
- Antimicrobial stewardship programs (ASPs) face challenges with electronic systems, leading to manual data searches and workflow interruptions.
- Inefficient information access hinders the ability of ASPs to prospectively audit antimicrobial use and provide timely feedback to clinicians.
Purpose of the Study:
- To identify information needs and workflow gaps within current electronic applications and reports for ASPs.
- To develop and implement new applications to improve the prospective auditing capabilities of ASPs and enhance antimicrobial use.
Main Methods:
- A framework was developed to integrate patient data from electronic medical records, data warehouses, and alert files.
- New applications were created using input from pharmacists and infectious disease physicians, aligning with CDC/NHSN antibiotic utilization specifications.
- Alerts and reports were generated and disseminated via pagers, emails, and the National Healthcare Surveillance Network (NHSN).
Main Results:
- Four novel applications were successfully developed and implemented at Intermountain Medical Center (IMC) and Primary Children's Hospital (PCH).
- These applications facilitated the use of updated CDC/NHSN antibiotic utilization specifications.
- Data from IMC and PCH demonstrated a general decrease in the targeted antimicrobial drug utilization.
Conclusions:
- Effective ASPs require substantial amounts of timely and accessible patient information.
- The newly developed applications significantly improved the efficiency of antimicrobial use review and patient prioritization.
- These advancements enable ASPs to optimize patient care through more effective antimicrobial stewardship.
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