Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molecular Models02:00

Molecular Models

45.8K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
45.8K
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

28.5K
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
28.5K
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

411
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
411

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Analysis of the Response Time to the Push Button in the Epilepsy Monitoring Unit.

The Neurodiagnostic journal·2026
Same author

Physical genomics: Why gene regulation is tug of war between polymer physics and biochemistry.

Current opinion in structural biology·2026
Same author

Socioeconomic inequity in extreme outcomes within very pre-term and/or very low birthweight infants: evidence from multi-national cohorts.

Frontiers in public health·2026
Same author

Discovery of gene-alcohol interaction loci influencing blood pressure in 1.1 million individuals from multiple populations.

Research square·2026
Same author

Implementation of and findings from a regional shoulder replacement registry.

Canadian journal of surgery. Journal canadien de chirurgie·2026
Same author

Cultivating interest in gerontological nursing among nursing students: evaluation of an educational initiative.

Nursing older people·2026
Same journal

TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.

Biochemical Society transactions·2026
Same journal

Advancing the monitoring of organelle contact sites in vitro and in vivo.

Biochemical Society transactions·2026
Same journal

Mechanisms influencing transient cytoplasmic protein targeting to intracellular lipid droplets.

Biochemical Society transactions·2026
Same journal

Replication associated nuclear DNA mismatch repair across kingdoms.

Biochemical Society transactions·2026
Same journal

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.

Biochemical Society transactions·2026
Same journal

Implications of Rho GTPase signaling in cancer immunotherapy.

Biochemical Society transactions·2026
See all related articles

Related Experiment Video

Updated: Apr 15, 2026

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

3.5K

Modelling biomacromolecular assemblies with continuum mechanics.

Benjamin Hanson1, Robin Richardson1, Robin Oliver2

  • 1*School of Physics and Astronomy, University of Leeds, Leeds, West Yorkshire, LS2 9JT, U.K.

Biochemical Society Transactions
|April 8, 2015
PubMed
Summary
This summary is machine-generated.

We developed fluctuating finite element analysis (FFEA) to model protein shape changes from thermal motion. This mesoscale method offers a new way to study biomolecular dynamics, distinct from atomic-level simulations.

More Related Videos

Interactive Molecular Model Assembly with 3D Printing
06:15

Interactive Molecular Model Assembly with 3D Printing

Published on: August 13, 2020

11.2K
Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

11.7K

Related Experiment Videos

Last Updated: Apr 15, 2026

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

3.5K
Interactive Molecular Model Assembly with 3D Printing
06:15

Interactive Molecular Model Assembly with 3D Printing

Published on: August 13, 2020

11.2K
Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

11.7K

Area of Science:

  • Biophysics
  • Computational Biology
  • Protein Dynamics

Background:

  • Conventional molecular dynamics (MD) simulations track individual atomic positions.
  • Understanding protein shape changes is crucial for biomolecular function.
  • Mesoscale modeling offers a complementary approach to atomic detail.

Purpose of the Study:

  • To introduce fluctuating finite element analysis (FFEA) for protein modeling.
  • To describe the theoretical underpinnings of FFEA.
  • To demonstrate FFEA's application in studying biomolecular dynamics.

Main Methods:

  • Developed a continuum mechanical description of proteins.
  • Utilized a finite element algorithm incorporating thermal fluctuations.
  • Generalized the algorithm to create FFEA.

Main Results:

  • FFEA provides trajectories of overall protein shape changes due to thermal agitation.
  • FFEA complements traditional MD by focusing on mesoscale dynamics.
  • Demonstrated FFEA's utility in modeling the dynein molecular motor.

Conclusions:

  • FFEA offers a novel method for simulating protein dynamics at the mesoscale.
  • This approach captures the collective motion of proteins influenced by thermal energy.
  • FFEA provides insights into the functional dynamics of molecular motors like dynein.