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Aging and liver disease.

In Hee Kim1, Tatiana Kisseleva, David A Brenner

  • 1aDepartment of Internal Medicine, Chonbuk National University Medical School, Jeonju, South Korea bDepartment of Internal Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA.

Current Opinion in Gastroenterology
|April 9, 2015
PubMed
Summary
This summary is machine-generated.

Aging increases liver injury vulnerability and disease severity. Older individuals and organs require tailored treatments due to diminished regenerative capacity and increased susceptibility to liver conditions.

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Area of Science:

  • Hepatology
  • Gerontology
  • Immunology

Background:

  • Aging is characterized by a decline in homeostasis, increasing chronic disease risk.
  • The liver's regenerative capacity is compromised with age.
  • Aging is a significant risk factor for numerous chronic diseases.

Purpose of the Study:

  • To review the impact of aging on clinical liver disease.
  • To examine the role of preclinical models in understanding aging-related liver pathogenesis.

Main Methods:

  • Literature review of aging effects on liver disease.
  • Inclusion of preclinical models for pathogenetic insights.

Main Results:

  • Aging exacerbates liver injury susceptibility and fibrotic responses.
  • Older age correlates with increased severity and poorer outcomes in liver diseases like NAFLD, ALD, and hepatitis C.
  • Liver transplantation in older recipients presents unique challenges.

Conclusions:

  • Liver disease treatment in older patients may necessitate modified or prolonged interventions.
  • Age-related changes impact liver transplant tolerance to injury.
  • Further research into aging mechanisms is crucial for developing novel therapeutic strategies against age-induced liver diseases.