Related Experiment Video
Updated: Apr 15, 2026

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
Published on: September 3, 2020
Myocardial extramedullary hematopoiesis following myocardial infarction
E F Marley1, H Liapis, J L Hess
1From the Lauren V. Ackerman Laboratory of Surgical Pathology, Barnes and St Louis Children's Hospitals, Washington University Medical Center, St Louis, Missouri, USA.
Abstract:
Extramedullary hematopoiesis (EMH) usually accompanies a chronic hematologic disease in adults or prematurity in neonates. We observed a striking case of EMH in the explanted heart of a 13-year-old boy who underwent transplantation after extensive myocardial infarction. The florid myeloid proliferation raised the possibility of a leukemic process. To our knowledge, extensive myocardial EMH subsequent to myocardial infarction has not been previously reported. Possible mechanisms underlying EMH in the myocardium are presented.
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