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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Nephrons01:10

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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

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Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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Amyloid nephropathy.

Mazdak A Khalighi1, W Dean Wallace2, Miguel F Palma-Diaz2

  • 1Department of Pathology , University of Chicago , Chicago, IL , USA.

Clinical Kidney Journal
|April 9, 2015
PubMed
Summary
This summary is machine-generated.

Amyloidosis involves abnormal protein buildup causing organ damage. This review details kidney amyloidosis, exploring various forms affecting renal function.

Keywords:
AAALALECT2amyloidosishereditary amyloidosis

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Area of Science:

  • Nephrology
  • Pathology
  • Biochemistry

Background:

  • Amyloidosis is a rare condition characterized by extracellular deposition of misfolded proteins, leading to organ dysfunction.
  • Kidney disease is a frequent complication of systemic amyloidosis.
  • Diverse amyloidogenic proteins can deposit in renal biopsy specimens.

Purpose of the Study:

  • To review the histopathologic features of renal amyloidosis.
  • To discuss specific types of amyloid affecting the kidney.

Main Methods:

  • Review of existing literature on renal amyloidosis.
  • Analysis of histopathologic characteristics of amyloid deposits.
  • Integration of proteomics findings in amyloidosis diagnosis.

Main Results:

  • General histopathologic features of amyloid deposition in the kidney are outlined.
  • Specific amyloidogenic proteins and their impact on renal pathology are discussed.

Conclusions:

  • Renal amyloidosis presents with distinct histopathologic findings.
  • Understanding the specific forms of amyloid is crucial for diagnosis and management.