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Use of ketamine in acute cases of suicidality
Jae Lee1, Puneet Narang1, Manasa Enja1
1Dr. Lee is resident physician at Hennepin-Regions Psychiatry Program, Minneapolis-St. Paul, Minnesota; Dr. Narang is staff physician and ECT psychiatrist, Regions Hospital, Minneapolis- St. Paul, Minnesota; Dr. Enja is observer physician, University of Louisville School of Medicine, Louisville, Kentucky; and Dr. Lippmann is Professor of Psychiatry, University of Louisville School of Medicine, Louisville, Kentucky.
Abstract:
Ketamine is an N-methyl-D- aspartate antagonist with rapid antidepressant effects. Research shows that ketamine has a fast onset of reduction in depressive symptoms and shows sustained remission of suicidal ideation in some patients. This article provides a brief review of the literature on the use of ketamine for depression and in acute cases of suicidality. The authors conclude that, while further investigation is needed, ketamine may be a useful treatment option for acute suicidality in emergency room settings.