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Endocrine-disrupting Chemicals: Review of Toxicological Mechanisms Using Molecular Pathway Analysis

Oneyeol Yang1, Hye Lim Kim1, Jong-Il Weon2

  • 1Department of Life Science, College of Life Sciences and Biotechnology, Dongguk University Biomedi Campus, Goyang ; Institute of Environmental Medicine, Dongguk University Biomedi Campus, Seoul.

Journal of Cancer Prevention
|April 9, 2015
PubMed

Insights

Endocrine disruptors harm humans by disrupting hormone systems, potentially causing obesity and cancer. Pathway analysis aids in understanding these toxic chemical mechanisms.

Area of Science:

  • Environmental Health
  • Toxicology
  • Bioinformatics

Background:

  • Endocrine disruptors (EDs) are chemicals that interfere with the body's hormone systems.
  • Accumulation of EDs is linked to severe health issues like obesity and cancer.
  • Understanding the molecular mechanisms of ED-induced diseases is crucial for public health.

Purpose of the Study:

  • To review the molecular mechanisms underlying diseases caused by endocrine disruptors.
  • To highlight the utility of pathway analysis in identifying toxicological mechanisms.
  • To present potential markers and signaling pathways affected by specific EDs.

Main Methods:

  • Literature review of studies on endocrine disruptors and associated diseases.
  • Focus on molecular mechanisms and biological pathways.
  • Application of pathway analysis, a bioinformatics tool, to predict chemical mechanisms.

Main Results:

  • Summarized major molecular mechanisms of ED-induced diseases.
  • Identified potential biomarkers and signaling pathways through pathway analysis.
  • Examined effects of bisphenol, diethylhexylphthalate, and nonylphenol exposure.

Conclusions:

  • Pathway analysis is a valuable bioinformatics tool for elucidating toxic chemical mechanisms.
  • Understanding EDs' molecular pathways is key to preventing associated diseases.
  • This review underscores the importance of bioinformatics in toxicological research.
Keywords:
Endocrine disruptorsMolecular mechanismObesogenPathway analysis

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