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Acute, reversible hepatic failure associated with methotrexate treatment of rheumatoid arthritis
D O Clegg1, D E Furst, K G Tolman
1Department of Medicine, University of Utah, School of Medicine, Salt Lake City.
The Journal of Rheumatology
|August 1, 1989
Abstract:
We describe 2 patients who developed reversible decompensated liver disease while taking pulse dosed methotrexate (MTX) for rheumatoid arthritis. One of the patients was available for biopsy and had chronic active hepatitis--a lesion not previously described with MTX. This appears to be a unique and unusual manifestation of MTX hepatotoxicity.