[Epigenetic mechanisms in post-stress states]

There is a continued interest in the research of epigenetic mechanisms of genes regulation in the brain, associated with the stress-induced adaptive and pathological consequences during the formation of post-stress states, in particular post-traumatic stress disorder (PTSD). Brief overview of epigenetic modifications was presented, while the process of DNA methylation was discussed comprehensively. Key stress-induced epigenetic changes in the human and animal brain in response to stress were summarized. Epigenetic modifications in certain genes (genes of stress responses, hormones and neurotransmitters genes, NGF gene) while post-stress states and PTSD formation were discussed in detail.