Related Experiment Video
Updated: Apr 15, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Synthesis, characterization, photophysics, and anion binding properties of platinum(ii) acetylide complexes with urea
Zhi-Hui Zhang1, Jiewei Liu, Li-Qi Wan
1MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. zhaoxy@mail.sysu.edu.cn.
Abstract:
A new class of platinum(ii) acetylide complexes with urea group, [Pt((t)Bu3tpy)(C[triple bond, length as m-dash]CC6H4-4-NHC(O)NHC6H4-4-R)](OTf) ((t)Bu3tpy = 4,4',4''-tri-tert-butyl-2,2':6',2''-terpyridine; R = H (), Cl (), CF3 (), and NO2 ()), has been synthesized and characterized. The crystal structures of , ·DMF·THF, ·CH3CN, and ·CH3CN have been determined by X-ray diffraction. Upon excitation at λ > 380 nm, the solid samples of complexes show orange light at 298 K. The anion binding properties of complexes have been studied by UV-vis titration experiments in CH3CN and DMSO. In general, the log K values of with the same anion in CH3CN depend on the substituent R on the acetylide ligand of and follow this order: R = NO2 () > CF3 () > Cl () > H (). For the same complex with different anions, the log K values are in the following order: F(-) > OAc(-) > Cl(-) > Br(-) ≈ HSO4(-) ≈ NO3(-) > I(-), which is in accordance with the decrease in the basicity of anions. Complex with NO2 group shows a dramatic colour change towards F(-) in DMSO, allowing the naked eye detection of F(-).
More Related Videos
10:51The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
12:08Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
Published on: June 24, 2022
Related Concept Videos
Basicity of Heterocyclic Aromatic Amines
Acidity of 1-Alkynes
The acidic strength of hydrocarbons follows the order: Alkynes > Alkenes > Alkanes. The strength of an acid is commonly expressed in units of pKa — the lower the pKa, the stronger the acid. Among the hydrocarbons, terminal alkynes have lower pKa values and are, therefore, more acidic. For example, the pKa values for ethane, ethene, and acetylene are 51, 44, and 25, respectively, as shown here.
Preparation of 1° Amines: Azide Synthesis
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary...
Preparation of Amines: Alkylation of Ammonia and Amines
Each alkylation step makes the nitrogen center more nucleophilic, which triggers successive alkylations until a quaternary ammonium salt is formed. Considering...
Structure of Amines