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Beyond Yellow Curry: Assessing Commercial Curcumin Absorption Technologies
Brad J Douglass1, Dallas L Clouatre
1a EAS Consulting Group , Alexandria , Virginia.
Journal of the American College of Nutrition
|April 10, 2015
Summary
Turmeric
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Nutritional Science
Background:
- Turmeric and its curcuminoids (curcumin, demethoxycurcumin, bisdemethoxycurcumin) show therapeutic promise but suffer from poor bioavailability.
- Formulation strategies are emerging to enhance curcuminoid absorption and bioactivity, yet comparative data is lacking.
- Different formulations may impact individual curcuminoid absorption unevenly, affecting physiological properties.
Purpose of the Study:
- To evaluate and compare the bioavailability of various commercial curcumin ingredients.
- To provide data for informed recommendations to healthcare professionals and consumers.
Main Methods:
- Comparative analysis of pharmacokinetic parameters from bioavailability studies.
- Utilized relative mass efficiency (E) to compare formulations with varying curcuminoid content.
Main Results:
- A hydrophilic carrier dispersed curcuminoid formula demonstrated 45.9 times higher bioavailability than standard purified curcuminoids.
- This formulation showed 1.5 times the bioavailability of the next best commercial ingredient, a cyclodextrin complex, based on relative mass efficiency.
- Delivery strategies significantly impact curcuminoid bioavailability.
Conclusions:
- Curcuminoid bioavailability is significantly enhanced by specific delivery strategies.
- Total formula mass is a critical factor for practical considerations like dosing, cost, and space.
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