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Updated: Apr 15, 2026
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Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
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Primary Transitional Cell Carcinoma of the Conjunctiva
Ashraf A Khan1, James R Cameron, Antonia Torgersen
1*Department of Ophthalmology, Princess Alexandra Eye Pavilion, Edinburgh; †Department of Neuropathology, Western General Hospital, Edinburgh; and ‡Department of Pathology, Southern General Hospital, Glasgow, United Kingdom.
Ophthalmic Plastic and Reconstructive Surgery
|April 10, 2015
Summary
A rare conjunctival transitional cell carcinoma in a 77-year-old male was successfully managed conservatively. This approach, involving surgery, topical mitomycin, and radiotherapy, achieved 4-year local control.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Conjunctival tumors are rare, with transitional cell carcinoma (TCC) being an uncommon subtype.
- Primary conjunctival TCC often presents diagnostic challenges and requires careful management strategies.
Observation:
- A 77-year-old male presented with a large, papillomatous lesion on the lower eyelid conjunctiva.
- Initial biopsy and systemic investigations confirmed primary conjunctival TCC.
Findings:
- Conservative management was chosen due to patient preference and comorbidities.
- The treatment regimen included surgical debulking, topical mitomycin-C, and radiotherapy.
- Local tumor control has been maintained for a follow-up period of 4 years.
Implications:
- This case highlights the feasibility of conservative management for conjunctival TCC.
- Multimodal therapy can achieve durable local control in select patients.
- Further research into optimal treatment protocols for conjunctival TCC is warranted.
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