Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MAPK-driven glioma progression and reprogramming of the tumor-associated immune response.

Neuro-oncology·2026
Same author

Human intracranial signal stability tracks anatomical accuracy after electrode reimplantation.

Journal of neural engineering·2026
Same author

Cerebrovascular vulnerability and fibrosis in human brain aneurysms.

Nature neuroscience·2026
Same author

Targeted Connectomic Neuromodulation of the Orbitofrontal Cortex To Treat Obsessive-Compulsive Disorder.

medRxiv : the preprint server for health sciences·2026
Same author

Opposing effects of slow and fast theta synchrony on working memory in the human hippocampal-orbitofrontal network.

bioRxiv : the preprint server for biology·2026
Same author

Real-time brain-controlled selective hearing enhances speech perception in multi-talker environments.

Nature neuroscience·2026
Same journal

Dynamic coordination and segregation mechanisms in higher cortex for parallel task processing.

Neuron·2026
Same journal

Higher-order thalamic bursts are drivers of attention control.

Neuron·2026
Same journal

Composing trajectories for rapid inference of navigational goals.

Neuron·2026
Same journal

Peri-head distance coding in the mouse brainstem.

Neuron·2026
Same journal

A two-timepoint framework for sensitive and specific single-cell activity screening.

Neuron·2026
Same journal

From first impressions to bonds: The neural dynamics of social relationships.

Neuron·2026
See all related articles

Related Experiment Video

Updated: Apr 15, 2026

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
09:44

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

6.2K

Towards large-scale, human-based, mesoscopic neurotechnologies.

Edward F Chang1

  • 1Department of Neurological Surgery and Department of Physiology, University of California, San Francisco, 675 Nelson Rising Lane, Room 511, San Francisco, CA 94158, USA.

Neuron
|April 10, 2015
PubMed
Summary
This summary is machine-generated.

Direct human brain recordings offer new neuroscience insights but face technological limits. Developing mesoscopic neural recording technologies could overcome these barriers for research and clinical use.

More Related Videos

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology
09:58

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology

Published on: July 21, 2018

24.2K
3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
10:14

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

7.7K

Related Experiment Videos

Last Updated: Apr 15, 2026

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
09:44

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

6.2K
Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology
09:58

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology

Published on: July 21, 2018

24.2K
3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
10:14

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

7.7K

Area of Science:

  • Neuroscience
  • Biotechnology
  • Medical Technology

Background:

  • Direct human brain recordings have significantly advanced neuroscience over the last decade.
  • Current progress relies on neurophysiological methods used during neurosurgical procedures.
  • This research setting, while valuable, imposes limitations on developing novel neurotechnologies.

Purpose of the Study:

  • To address the challenge of achieving high-resolution, large-scale spatiotemporal neural recordings in humans.
  • To explore new research directions for human-based neurotechnology development.
  • To bridge the gap between existing neurorecording approaches and future needs.

Main Methods:

  • Investigating neurophysiological approaches in patients undergoing neurosurgery.
  • Analyzing constraints and opportunities in current human brain recording techniques.
  • Proposing mesoscopic-scale resolution as a viable direction for neurotechnology.

Main Results:

  • Current methods provide valuable but limited data due to constraints of the clinical setting.
  • A significant challenge remains in scaling up neural recordings with high spatiotemporal resolution.
  • Mesoscopic-scale resolution offers a promising pathway to overcome current limitations.

Conclusions:

  • Developing new neurotechnologies requires addressing the limitations of current human brain recording methods.
  • Mesoscopic-scale neural recordings present a strategic approach to advance human-based neurotechnology.
  • This advancement has substantial implications for both fundamental neuroscience research and clinical translation.