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A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1
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Two tales (tails) of SAMHD1 destruction by Vpx
1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Cell Host & Microbe
|April 10, 2015
Abstract:
The lentivirus protein Vpx/Vpr recognizes the host restriction factor SAMHD1 at either its N- or C-terminal tail and targets it for destruction by the cellular protein degradation machinery. In this issue of Cell Host & Microbe, Schwefel et al. (2015) report the structural basis of SAMHD1 N-terminal targeting by Vpx.

