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Related Experiment Videos

[Effects of fentanyl on left ventricular diastolic function].

T Tamura

    Masui. the Japanese Journal of Anesthesiology
    |October 1, 1989
    PubMed
    Summary

    Fentanyl, an anesthetic, did not significantly impair left ventricular diastolic function in dogs, even with a reduced heart rate. Diastolic filling period and filling volume increased, suggesting preserved cardiac function during anesthesia.

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    Area of Science:

    • Cardiology
    • Anesthesiology
    • Physiology

    Context:

    • Fentanyl is a potent opioid analgesic commonly used in anesthesia.
    • Left ventricular diastolic function is crucial for adequate cardiac output.
    • Assessing anesthetic effects on cardiac function is vital for patient safety.

    Purpose:

    • To investigate the effects of fentanyl on left ventricular diastolic function in conscious, instrumented dogs.
    • To quantify changes in specific diastolic indices under varying fentanyl doses.
    • To determine if fentanyl impairs diastolic function in the absence of surgical stress.

    Summary:

    • Fentanyl administration (10, 50, 100 mcg.kg-1) did not significantly alter most left ventricular diastolic indices, including isovolumic relaxation period and peak rapid filling rate.
    • Despite a ~50% decrease in heart rate, the diastolic filling period and filling volume showed significant increases.
    • Minor decreases in peak rapid filling rate and the derivative of left ventricular pressure were observed only at the lowest fentanyl dose (10 mcg.kg-1).

    Impact:

    • This study suggests that fentanyl, when administered without surgical stress, does not adversely affect left ventricular diastolic function.
    • Findings support the safe use of fentanyl for its analgesic and anesthetic properties in cardiovascular procedures.
    • Provides valuable data for anesthesiologists and cardiologists regarding opioid anesthetic effects on cardiac physiology.

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