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[Preparation technology optimization of xiaozhong cataplasm by central composite design-response surface method and
Objective:
To optimize the preparation technology of Xiaozhong Cataplasm and to evaluate its preliminary clinical effect.
Methods:
The viscosity, residue and appearance were selected as evaluation indexes. The central composite design-response surface methodology was applied to optimize the amounts of Skeleton material, tackifier and crosslinking agent. Clinical effect of Xiaozhong Cataplasm was observed.
Results:
The optimal formulation was HQ841: PVP k120: PVPP: aluminium glycinate: water: glycerin: ethanol = 4:3:2:0.15: 60:25:10. The effective rate of the cataplasm was 97.22% and 91.67% had marked effect.
Conclusion:
Prepared by the optimal preparation technology, the cataplasm has the moderate viscosity and little residue with good clinical effect.
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