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Metallothionein immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour
Aline-Cristina-Batista-Rodrigues Johann1, Patrícia-Carlos Caldeira, Marcelo-Vidigal Caliari
1Universidade Federal de Minas Gerais, Faculdade de Odontologia, Av. Antônio Carlos, 6627 sala 3201, Pampulha, Belo Horizonte, MG, Brasil, pat_caldeira@yahoo.com.br.
Background:
To compare the metallothionein (MT) immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour (KOT), to correlate MT with cellular proliferation, and to evaluate the influence of inflammation in MT.
Study Design:
Fourteen cases of KOT were submitted to immunohistochemistry for MT and Ki-67 analysis. The lesions were grouped according to their grade of inflammation, and statistical analysis was performed.
Results:
MT was higher in non-syndromic KOT than in syndromic KOT (p<0.05). No statistical difference in Ki-67 could be identified; however, an inverse correlation was observed between MT and Ki-67 in both lesions. When analysing inflammation, non-syndromic KOT showed no differences in either MT or Ki-67.
Conclusions:
The MT immunophenotype of syndromic KOT was different from non-syndromic KOT. MT might not be involved in the proliferation control of both KOT. MT and Ki-67 immunoexpressions proved to be unaffected by inflammation in non-syndromic KOT.
