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NiO Nanoflowers for Non-Enzymatic Amperometric Detection of Glucose

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Published on: December 30, 2025

Gelatin-ionic liquid based platform for glucose detection.

Anshu Sharma, Kamla Rawat, Pratima R Solanki¹

¹Special Centre for Nanosciences, Jawaharlal Nehru University, New Delhi-110067, India. pratimarsolanki@gmail.com.

Current Topics in Medicinal Chemistry

|April 11, 2015

Summary

This summary is machine-generated.

We developed a novel bioelectrode using gelatin and ionic liquid for glucose detection. This platform offers a promising approach for sensitive and efficient glucose monitoring using electrochemical and optical methods.

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Area of Science:

Biomaterials Science
Electrochemistry
Biosensors

Background:

Developing sensitive and reliable biosensors for glucose detection is crucial for diabetes management.
Ionic liquids offer unique properties for biomaterial functionalization and sensor development.

Purpose of the Study:

To fabricate and characterize a novel bioelectrode platform based on gelatin-ionic liquid ionogels for glucose detection.
To investigate the electrochemical and optical sensing capabilities of the fabricated bioelectrode for glucose.

Main Methods:

Fabrication of gelatin-ionic liquid ionogels on indium tin oxide (ITO) coated glass.
Immobilization of glucose oxidase (GOx) onto the ionogel-modified ITO electrode.
Characterization using scanning electron microscopy, Fourier transform infrared spectroscopy, and cyclic voltammetry.
Electrochemical and optical monitoring of glucose concentration.

Main Results:

The [C2mim][Cl] ionic liquid enhanced the electrocatalytic behavior of the electrode, yielding a high electron transfer rate constant (Ks ≈ 0.113 s⁻¹).
Electrochemical detection showed linearity from 1-20 mM glucose with a low Michaelis-Menten constant (Km ≈ 0.174 mM) and sensitivity of 4.6µA mM⁻¹ cm⁻².
Optical detection demonstrated linearity from 6-20 mM glucose with Km ≈ 3.8 mM and sensitivity of 6.76 x 10⁻³ Abs/mM cm².

Conclusions:

The developed gelatin-ionic liquid ionogel-based bioelectrode is a promising platform for sensitive glucose detection.
The enhanced electrocatalytic properties and dual detection modes (electrochemical and optical) offer a versatile biosensing solution.