Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A single-echo/multi-echo BOLD fMRI test-retest dataset.

Data in brief·2026
Same author

Cannabis use and glutamate across the psychosis spectrum: in vivo evidence from 7T proton magnetic resonance spectroscopy.

Molecular psychiatry·2026
Same author

An open, fully-processed data resource for studying mood and sleep variability in the developing brain.

Aperture neuro·2026
Same author

The Hidden Architecture of Brain Structural Variability in 22q11.2 Deletion Syndrome: A Multi-site Study.

medRxiv : the preprint server for health sciences·2026
Same author

Premorbid adjustment problems, negative symptoms, and cognitive impairment in a large international sample at clinical high risk for psychosis: Findings from the Accelerating Medicines Partnership-Schizophrenia.

Schizophrenia bulletin·2026
Same author

The PMADS Project: A Longitudinal Multimodal Cohort Study to Understand Risk for Perinatal Mood and Anxiety Disorders.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Apr 15, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.7K

The Philadelphia Neurodevelopmental Cohort: constructing a deep phenotyping collaborative.

Monica E Calkins1, Kathleen R Merikangas2, Tyler M Moore1

  • 1University of Pennsylvania, Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, PA, United States.

Journal of Child Psychology and Psychiatry, and Allied Disciplines
|April 11, 2015
PubMed
Summary

The Philadelphia Neurodevelopmental Cohort (PNC) study found that psychopathology in youths can be categorized into general and specific factors, aiding research into mental disorders. This data is valuable for understanding gene-brain-behavior links in youth mental health.

Keywords:
Community cohortadolescentsanxietybehaviorchildrencomorbiditygenomicsmoodneurocognitionneuroimagingpsychopathologypsychosispublic domainstructureyoung adults

More Related Videos

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

2.2K
Streamlined 3D Cerebellar Differentiation Protocol with Optional 2D Modification
10:15

Streamlined 3D Cerebellar Differentiation Protocol with Optional 2D Modification

Published on: December 9, 2017

8.1K

Related Experiment Videos

Last Updated: Apr 15, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.7K
Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

2.2K
Streamlined 3D Cerebellar Differentiation Protocol with Optional 2D Modification
10:15

Streamlined 3D Cerebellar Differentiation Protocol with Optional 2D Modification

Published on: December 9, 2017

8.1K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics
  • Developmental Psychology

Background:

  • Understanding neurodevelopmental trajectories of mental disorders requires an integrative, multidisciplinary approach.
  • The Philadelphia Neurodevelopmental Cohort (PNC) was established to characterize clinical and neurobehavioral phenotypes in genotyped youths.
  • PNC data is now publicly available via the NIMH Database of Genotypes and Phenotypes (dbGaP).

Purpose of the Study:

  • To provide an overview of PNC recruitment and clinical assessment methods for the scientific community.
  • To evaluate the structure and criterion validity of the assessment tools used in the PNC.
  • To enable informed use and interpretation of the PNC resource.

Main Methods:

  • Recruited 9,498 youths (aged 8-21) from a larger pool previously genotyped at The Children's Hospital of Philadelphia.
  • Developed and administered a comprehensive computerized tool for structured evaluation of psychopathology domains (GOASSESS).
  • Utilized factor analysis to evaluate the structure of the GOASSESS tool.

Main Results:

  • Factor analysis revealed a strong general psychopathology factor and specific factors: 'anxious-misery', 'fear', and 'behavior'.
  • The 'behavior' factor showed a negative correlation with neurocognitive performance, especially executive functions.
  • Sex differences were observed, with females higher on 'anxious-misery' and lower on 'behavior' factors; psychosis spectrum symptoms also showed distinct factor structures.

Conclusions:

  • The PNC assessment yielded psychopathology data with strong factorial validity in a diverse cohort of genotyped youths.
  • PNC factor scores are suitable for dimensional integration with other data modalities like neuroimaging and genomics.
  • PNC resources can advance the understanding of gene-cognition-brain-behavior relationships in the neurodevelopment of common mental disorders.