Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Changes in complement breakdown products and terminal complement complex in patients with acute glomerulonephritis].

H Kojima, H Ohi, M Seki

    Nihon Jinzo Gakkai Shi
    |September 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Improved nitric oxide detection using 2,3-diaminonaphthalene and its application to the evaluation of novel nitric oxide synthase inhibitors.

    Biological & pharmaceutical bulletin·1999
    Same author

    Brain tumors in surgical neuropathology of intractable epilepsies, with special reference to cerebral dysplasias.

    Brain tumor pathology·1999
    Same author

    Anaplastic large-cell lymphoma of null-cell type with multiple bone involvement.

    Annals of hematology·1999
    Same author

    Influence of speech-coding strategy on cortical activity in cochlear implant users: a positron emission tomographic study.

    Acta oto-laryngologica·1998
    Same author

    Differential induction by methyl jasmonate of genes encoding ornithine decarboxylase and other enzymes involved in nicotine biosynthesis in tobacco cell cultures.

    Plant molecular biology·1998
    Same author

    Increased intestinal glucose absorption and postprandial hyperglycaemia at the early step of glucose intolerance in Otsuka Long-Evans Tokushima Fatty rats.

    Diabetologia·1998
    Same journal

    [A case of renal Fanconi syndrome due to Bence Jones' protein K-type multiple myeloma].

    Nihon Jinzo Gakkai shi·2019
    Same journal

    [Association of blood pressure control effects on renal impairment with urinary protein: a study on the validity of the Japanese Society of Hypertension Guidelines for Management of Hypertension 2014].

    Nihon Jinzo Gakkai shi·2019
    Same journal

    [Contrast-induced nephropathy].

    Nihon Jinzo Gakkai shi·2019
    Same journal

    [Immunosuppressants-induced kidney injury].

    Nihon Jinzo Gakkai shi·2019
    Same journal

    [Drug-induced kidney injury due to antibiotic agents].

    Nihon Jinzo Gakkai shi·2019
    Same journal

    [Drug-induced kidney injury of anticancer chemotherapeutic drugs].

    Nihon Jinzo Gakkai shi·2019
    See all related articles

    The complement system plays a key role in acute glomerulonephritis (AGN). Complement activation, particularly via the classical pathway, is observed in early AGN stages and contributes to kidney inflammation.

    Area of Science:

    • Nephrology
    • Immunology
    • Biochemistry

    Background:

    • The study investigates the involvement of the complement system in acute glomerulonephritis (AGN).
    • Complement activation products and the terminal complement complex (TCC) were quantified in patient plasma using ELISA.
    • The assay is designed for accurate measurement of in vivo complement activation.

    Observation:

    • Plasma levels of complement breakdown products (iC3b, C4d) and TCC (SC5b-9) were elevated in some glomerulonephritis patients.
    • Increased iC3b/C3 and C4d/C4 ratios were noted in early AGN stages, suggesting classical pathway involvement.
    • Plasma SC5b-9 concentrations were significantly increased in early AGN, with deposition observed in renal glomeruli.

    Findings:

    • Complement activation, predominantly via the classical pathway, leads to TCC formation in AGN.

    Related Experiment Videos

  • Elevated iC3b, C4d, and SC5b-9 levels indicate active complement system engagement in AGN.
  • Renal deposition of complement components (C3c, C3d, C4d, SC5b-9) was confirmed in AGN patients.

    • Implications:

    • Complement activation in blood and renal tissue is implicated in the initiation and progression of AGN.
    • Targeting complement pathways may offer therapeutic strategies for managing AGN.
    • Understanding complement's role provides insights into glomerulonephritis pathogenesis.