Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for k_a Estimation

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pre-steady state kinetic analysis of HIV-1 reverse transcriptase for non-canonical ribonucleoside triphosphate incorporation and DNA synthesis from ribonucleoside-containing DNA template.

Antiviral research·2015

Same author

Combined lateral femoral epicondylar osteotomy and a submeniscal approach for the treatment of a tibial plateau fracture involving the posterolateral quadrant.

Injury·2014

Same author

Effects of a continuous electromagnetic field on wound healing in human airway.

The Laryngoscope·2014

Same author

Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on trypanosoma brucei by forming an adduct with trypanothione.

Molecular pharmacology·2014

Same author

Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses.

Retrovirology·2014

Same author

Arctigenin Increases Hemeoxygenase-1 Gene Expression by Modulating PI3K/AKT Signaling Pathway in Rat Primary Astrocytes.

Biomolecules & therapeutics·2014

Search research articles

Related Experiment Video

Updated: Apr 15, 2026

Assembly and Characterization of Polyelectrolyte Complex Micelles

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

Improved estimation of myelin water fraction using complex model fitting.

Yoonho Nam¹, Jongho Lee², Dosik Hwang³

¹Department of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea; Department of Electrical and Computer Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-744, Republic of Korea.

|April 11, 2015

Summary

Gradient echo imaging of white matter myelin water requires complex-valued models. A new complex model fitting approach, applied to complex data without background phase removal, demonstrated the most stable myelin water signal estimation.

Keywords:

B(0) field inhomogeneity Fiber orientation Frequency offset Myelin water T(2)(⁎) relaxation White matter

More Related Videos

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

Related Experiment Videos

Last Updated: Apr 15, 2026

Assembly and Characterization of Polyelectrolyte Complex Micelles

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

Area of Science:

Magnetic Resonance Imaging
Neuroimaging
Biophysics

Background:

Gradient echo (GRE) imaging reveals frequency shifts in white matter water compartments (myelin, axonal, extracellular).
These shifts depend on fiber orientation and the B0 field, suggesting complex-valued signal models for GRE-based myelin water imaging.

Purpose of the Study:

To investigate the reliability of different signal models and fitting approaches for myelin water imaging in GRE.
To compare magnitude and complex models fitted to magnitude or complex data.

Main Methods:

Evaluated three signal models: magnitude model (magnitude data), complex model (magnitude data), and complex model (complex data).
Proposed a novel fitting approach for the complex model using complex data, eliminating the need for background phase removal.

Main Results:

The complex model fitted to complex data, using the new approach, yielded the most stable parameter estimation.
Comparison revealed superior reliability of the complex model fitting to complex data.

Conclusions:

Complex-valued signal modeling is essential for accurate GRE-based myelin water imaging.
The proposed complex model fitting approach offers enhanced stability and reliability in myelin water quantification.